Lymphoma classification

Lymphoma classification

Lymphoma has undergone many classification systems over the decades. Shown here is the most current system. Click on any type of lymphoma below to see more information about it. Older systems are shown here.  Click on any type of lymphoma below to go to more information about that type. If your type does not have a link then use the Advanced Search link above to search prestigious medical journals for more information about it.

 2016 WHO classification

Mature B-cell neoplasms

• Chronic lymphocytic leukemia/small lymphocytic lymphoma
• Monoclonal B-cell lymphocytosis*
• B-cell prolymphocytic leukemia
• Splenic marginal zone lymphoma
• Hairy cell leukemia
• Splenic B-cell lymphoma/leukemia, unclassifiable
  • Splenic diffuse red pulp small B-cell lymphoma
  • Hairy cell leukemia-variant
• Lymphoplasmacytic lymphoma
  • Waldenström macroglobulinemia
• Monoclonal gammopathy of undetermined significance (MGUS), IgM*
• μ heavy-chain disease
• γ heavy-chain disease
• α heavy-chain disease
• Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*
• Plasma cell myeloma
• Solitary plasmacytoma of bone
• Extraosseous plasmacytoma
• Monoclonal immunoglobulin deposition diseases*
• Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
• Nodal marginal zone lymphoma
  • Pediatric nodal marginal zone lymphoma
• Follicular lymphoma
  • In situ follicular neoplasia*
  • Duodenal-type follicular lymphoma*
• Pediatric-type follicular lymphoma*
• Large B-cell lymphoma with IRF4 rearrangement*
• Primary cutaneous follicle center lymphoma
• Mantle cell lymphoma
  • In situ mantle cell neoplasia*
• Diffuse large B-cell lymphoma (DLBCL), NOS
  • Germinal center B-cell type*
  • Activated B-cell type*
• T-cell/histiocyte-rich large B-cell lymphoma
• Primary DLBCL of the central nervous system (CNS)
• Primary cutaneous DLBCL, leg type
• EBV+ DLBCL, NOS*
• EBV+ mucocutaneous ulcer*
• DLBCL associated with chronic inflammation
• Lymphomatoid granulomatosis
• Primary mediastinal (thymic) large B-cell lymphoma
• Intravascular large B-cell lymphoma
• ALK+ large B-cell lymphoma
• Plasmablastic lymphoma
• Primary effusion lymphoma
• HHV8+ DLBCL, NOS*
• Burkitt lymphoma
• Burkitt-like lymphoma with 11q aberration*
• High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*
• High-grade B-cell lymphoma, NOS*
• B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

Mature T and NK neoplasms

• T-cell prolymphocytic leukemia
• T-cell large granular lymphocytic leukemia
• Chronic lymphoproliferative disorder of NK cells
• Aggressive NK-cell leukemia
• Systemic EBV+ T-cell lymphoma of childhood*
• Hydroa vacciniforme–like lymphoproliferative disorder*
• Adult T-cell leukemia/lymphoma
• Extranodal NK-/T-cell lymphoma, nasal type
• Enteropathy-associated T-cell lymphoma
• Monomorphic epitheliotropic intestinal T-cell lymphoma*
• Indolent T-cell lymphoproliferative disorder of the GI tract*
• Hepatosplenic T-cell lymphoma
• Subcutaneous panniculitis-like T-cell lymphoma
• Mycosis fungoides
• Sézary syndrome
• Primary cutaneous CD30+ T-cell lymphoproliferative disorders
  • Lymphomatoid papulosis
  • Primary cutaneous anaplastic large cell lymphoma
• Primary cutaneous γδ T-cell lymphoma
• Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
• Primary cutaneous acral CD8+ T-cell lymphoma*
• Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*
• Peripheral T-cell lymphoma, NOS
• Angioimmunoblastic T-cell lymphoma
• Follicular T-cell lymphoma*
• Nodal peripheral T-cell lymphoma with TFH phenotype*
• Anaplastic large-cell lymphoma, ALK+
• Anaplastic large-cell lymphoma, ALK−*
• Breast implant–associated anaplastic large-cell lymphoma*
• Hodgkin lymphoma
• Nodular lymphocyte predominant Hodgkin lymphoma
• Classical Hodgkin lymphoma
  • Nodular sclerosis classical Hodgkin lymphoma
  • Lymphocyte-rich classical Hodgkin lymphoma
  • Mixed cellularity classical Hodgkin lymphoma
  • Lymphocyte-depleted classical Hodgkin lymphoma

Posttransplant lymphoproliferative disorders (PTLD)

• Plasmacytic hyperplasia PTLD
• Infectious mononucleosis PTLD
• Florid follicular hyperplasia PTLD*
• Polymorphic PTLD
• Monomorphic PTLD (B- and T-/NK-cell types)
•  Classical Hodgkin lymphoma PTLD

Histiocytic and dendritic cell neoplasms

•  Histiocytic sarcoma
•  Langerhans cell histiocytosis
•  Langerhans cell sarcoma
•  Indeterminate dendritic cell tumor
•  Interdigitating dendritic cell sarcoma
•  Follicular dendritic cell sarcoma
•  Fibroblastic reticular cell tumor
•  Disseminated juvenile xanthogranuloma
•  Erdheim-Chester disease*

* Indicates a provisional entity

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Introduction to a review series: the 2016 revision of the WHO classification of tumors of hematopoietic and lymphoid tissues

Click here to view older classification systems