Spread:

The spread reflects the natural circulation of lymphocytes.

(a) Tumor arising in Lymph nodes spread to:

• 1)Other nodes
• 2)Bone marrow
• 3) Spleen
  

(b)Tumor arising in extra nodal sites may show 'ecotaxis'i.e. a homing instinct and can spread first to the contra lateral organ. from one breast to other or one place in intestine to the other place in intestine.