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NHL for Dummies First of all, lymphoma is not a disease of the lymphatic system. It is a disease of lymphocytes, a form of white blood cells, which circulate throughout the body in the blood and lymphatic systems. See below for a description of the lymphatic system: The lymphatic system and the blood system together form the circulatory system and connect to every part of the body. Blood cells originate in the bone marrow. Lymphocytes are the "brain cells" of the immune system. They direct the actions of the other cells involved in fighting off diseases, cancers, etc. When faced with an invader, or simply a damaged cell, lymphocytes reproduce, quite rapidly, in fact, and activate the other parts of the immune system. When this occurs, these lymphocytes are called "reactive." When they've done their job, most of the newly born lymphocytes die an honorable death and things return to normal. Sometimes, however, a good lymphocyte goes bad. It reproduces and keeps reproducing for no good reason. The newly born lymphocytes don't die an honorable death, but hang on and produce more bad lymphocytes. When this gets out of control, it is called "lymphoma." There are many different times and places in the life cycle of a lymphocyte where things can go wrong. Depending on when and how the lymphocyte goes bad determine the particular type and grade of lymphoma. Just how wide spread the bad lymphocytes go determines the stage. If they hang around the local candy store (oops, I mean a single lymph node) then it is called stage one. If instead they rampage throughout the city (body), getting into all different kinds of places, then it might be called stage IV. Even in lymphoma patients, most lymphocytes are good citizens, doing their job quietly, having kids when necessary, etc. The other kinds of white blood cells are also normal. It's just this one criminal family that's causing all the problems. If this lymphoma mob is aggressive and keeps growing, then you can send out the cops (chemotherapy, radiation) to arrest (shoot on sight, actually) any lymphocyte acting aggressively. Unfortunately, any other cells that are growing quickly at the same time are subject to the same martial law. This is what causes side effects. If the mob is indolent (lazy) they can't be identified as readily and the cops can't wipe all of them out. But they can do a good job of keeping them in check for many years. Sometimes mobster lymphocytes sneak into the nursery (bone marrow) where newborn blood cells grow to maturity. This makes it easier for the mobsters evil kin to spread. (Bone marrow involvement) Sometimes, with an aggressive mob, the cops just can't handle it. Then it's time to call out the military. They just kill everyone in the city (high dose chemotherapy.) Unfortunately this also wipes out the nursery. Fortunately, before they bomb the place, they save enough newborns (stem cells) to repopulate the nursery and go forth into the now empty city. If they can't get enough healthy babies from the city (the body) the powers that be find some other city (bone marrow donor) and take some of their baby cells to repopulate after the high-dose chemo. (This is called a stem cell rescue or bone marrow transplant.) After this, the city is left with some damage, but often continues normally from then on. I think I've confused myself enough at this point, so I'll quit for now. © 1999 Robert Scott Pallack The Lymphatic System Lymphatic Capillaries Lymphatic Vessels Formation of a Lymph Infection Immunity B-Cells produce antibodies that act against specific antigens, allowing for antibody-mediated immunity Antibodies are composed of soluble proteins called immunoglobulins. Three most abundant types:IgG IgA Igm Thymus Spleen |