Classification |
B Cell Antigens |
T Cell Antigens |
Other Antigens |
Genetic Features |
CD19 |
CD20 |
CD22 |
CD2 |
CD3 |
CD5 |
CD7 |
CD4 / CD8 |
B Cell Lymphomas |
Precursor B-lymphoblastic leukemia/lymphoma (B-LBL) |
+ |
-/+ |
+ |
- |
- |
- |
- |
- |
CD10+/-; CD13 ps; CD33 ps; CD34+/-; HLADR+; sIg-; cytoplasmic mu -/+; TdT+ |
Ig HC rg; Ig LC rg-ps; TCR rg (mn) |
B-Cell Chronic Lymphocytic Leukemia (B-CLL)/ Prolymphocytic Leukemia (B-PLL)/ Small Lymphocytic Leukemia (B-SLL) |
+ |
+ |
+ |
- |
- |
+ |
- |
- |
CD10-; CD11c-/+ (ft); CD23+; CD43+; sIgM ft; sIgD+/-; cIg-/+ |
Ig HC & LC rg; +12 (33%); ab 13q (¾25%); t(11;14) & bcl-1 rg reported |
Lymphoplasmacytoid Lymphoma |
+ |
+ |
+ |
- |
- |
- |
- |
- |
CD10-; CD11c ps (ft); CD25 ps (ft); CD43+/-; sIg+; cIg+; (us M); IgD- (us) |
Ig HC & LC rg |
Mantle Cell Lymphoma |
+ |
+ |
+ |
- |
- |
+ |
- |
- |
CD10-/+; CD11c-; CD23-; CD43+; sIgM+; IgD+ (us); lambda > kappa; disorganized FDC |
mj t(11;14) w/Ig HC & bcl-1 |
Follicle Center Lymphoma, Follicular; Grades: I (Predominantly Small Cell); II (Mixed); III (Predominantly Large Cell); Provisional Subtype: Diffuse (Predominantly Small Cell) |
+ |
+ |
+ |
- |
- |
- |
- |
- |
CD10+/-; CD11c-; CD23-/+; CD43-; sIg+ (M+/-D > G > A); Bcl-2+ in follicles; organized FDC |
t(14;18) w/bcl-2 (70-95%) |
Marginal Zone B-Cell Lymphoma; 1)Extranodal: Low-grade B-cell lymphoma of MALT type (+/- monocytoid B-cells); 2) Nodal: (+/- monocytoid B-cells) |
+ |
+ |
+ |
- |
- |
- |
- |
- |
CD10-; CD11c+/-; CD23-; CD43-/+; sIg+ (M >G or A); IgD-; cIg+ (40%) |
No bcl-1 or bcl-2 rg; +3 and/or t(11;18) reported in extranodal type |
Splenic Marginal Zone Lymphoma, w/ or w/o Villous Lymphocytes (provisional entity) |
+ |
+ |
+ |
- |
- |
- |
- |
- |
CD10-; CD11c+/-; CD23-; CD43-/+; CD25-; sIg+ (M>G or A; lack IgD); cIg+ (40%); TRAP- |
Not well studied; +3 nd |
Hairy Cell Leukemia |
+ |
+ |
+ |
- |
- |
- |
- |
- |
CD10-; CD11c+ (st); CD23-; CD25+ (st); CD103+; sIg+ (M+/- D, G or A); FMC7+; TRAP+ (mj) |
Ig HC & LC rg |
Plasmacytoma/Plasma Cell myeloma |
- |
- |
- |
- |
- |
- |
- |
- |
CD30+; CD38+; CD43+/-; CD45-/+; CD56+/-; sIg-; cIg+ (G, A, rare D/E; or LC only); HLADR/+; EMA-/+ |
Ig HC & LC rg or deleted |
Diffuse Large B-Cell Lymphoma |
+ |
+ |
+ |
- |
- |
-/+ |
- |
- |
CD10-/+; CD45+/-; sIg+/-; cIg-/+ |
bcl-2 rg (30%); c-myc rg (rp); bcl-6 rg; EBV+ in PTLD, HIV |
Primary Mediastinal (Thymic) Large B-Cell Lymphoma (Large B-Cell Lymphoma Subtype) |
+ |
+ |
+ |
- |
- |
- |
- |
- |
CD15-; CD30-/+; CD45+/-; sIg- |
Ig HC & LC rg |
Burkitt's Lymphoma |
+ |
+ |
+ |
- |
- |
- |
- |
- |
CD10+; CD23-; sIgM+ |
t(8;14); t(2;8); or t(8;22) of c-myc |
High-Grade B-Cell Lymphoma, Burkitt-like (provisional entity) |
+ |
+ |
+ |
- |
- |
- |
- |
- |
CD10- (us); sIg+/-; cIg ps |
bcl-2 rg (30%); c-myc rg (un) |
T Cell Lymphomas |
|
|
|
|
|
|
|
|
|
|
Precursor T-Lymphoblastic Lymphoma/Leukemia (T-LBL) |
- |
- |
- |
+/- |
+/- |
+/- |
+ |
CD4+/ CD8+ or CD4- / CD8- |
CD1a+/-; cytoplasmic CD3; CD16 oc; CD57 oc; TdT+; Ig-; alpha-beta or gamma-delta or no TCRs |
TCR rg (vr); Ig HC (ps) |
T-Cell Chronic Lymphocytic Leukemia (T-CLL)/T-Prolymphocytic Leukemia (T-PLL) |
- |
- |
- |
+ |
+ |
+ |
+ |
CD4+ / CD8-(65%); CD4+/CD8+ (21%); CD4-/CD8+ rare |
CD25- |
clonal TCR rg: inv14(q11; q32) in 75%; +8q |
T-Cell Large Granular Lymphocyte Leukemia (T-LGL) |
- |
- |
- |
+ |
+ |
- |
- |
CD4-/CD8+ |
CD16+; CD25-; CD56-/+; CD57+/-; TCRalpha/betaR+ |
clonal TCR rg |
NK-Cell Large Granular Lymphocyte (LGL) Leukemia (NK-LGL) |
- |
- |
- |
+ |
- |
- |
- |
- |
CD16+; CD56+/-; CD57+/-; TCRalpha/beta- |
TCR germ |
Mycosis Fungoides/ Sézary Syndrome |
- |
- |
- |
+ |
+ |
+ |
0.3 |
CD4+/CD8- |
CD25- (us) |
clonal TCR rg |
Peripheral T-Cell Lymphomas, Unspecified (Medium-, mixed Medium & Large-, Large-Cell) |
- |
ra |
- |
+/- |
+/- |
+/- |
-/+ |
CD4+ > CD8+;CD4-/CD8- ps |
CD45RA+ & CD45RO- (ps) |
TCR rg (us); Ig genes germ |
Angioimmunoblastic T-Cell Lymphoma |
- |
- |
- |
+ |
+ |
+ |
+ |
CD4+ > CD8+ |
expanded FDC surrounding venules |
TCR rg (75%); Ig HC rg (10%); EBV genome + (of); +3 and/or +5 (ps) |
Angiocentric Lymphoma |
- |
- |
- |
+ |
- (of) |
+/- |
+/- |
either + |
CD56+ (of) |
TCR & Ig germ; EBV genome + (us) |
Intestinal T-Cell Lymphoma (with or without Enteropathy) |
- |
- |
- |
+ |
+ |
+ |
+ |
CD4-/CD8+/- |
CD103+ |
clonal TCRbeta rg |
Adult T-Cell Lymphoma/Leukemia (ATL/L) |
- |
- |
- |
+ |
+ |
+ |
- |
CD4+ >> CD8+ |
CD25+ |
clonal TCR rg; clonal integrated HTLV-1 genome + |
Anaplastic large Cell (CD30+) Lymphoma (T- and Null-Cell Types) |
-/+ |
-/+ |
-/+ |
+/- |
-/+ |
vr |
vr |
vr |
CD15-/+; CD25+/-; CD30+; CD43-/+; CD45+/-; CD45RO-/+; CD68-5 EMA+/- |
t(2;5); TCR rg (50-60%) |
ALCL Hodgkin's-Like /Hodgkin's-related (provisional entity) |
-/+ |
-/+ |
-/+ |
+/- |
-/+ |
vr |
vr |
vr |
CD15-/+; CD25+/-; CD30+; CD43-/+; CD45+/-; CD45RO-/+; CD68-5; EMA+/-6; EBV- |
unknown |
Hodgkin's Disease (HD) |
|
|
|
|
|
|
|
|
|
|
Lymphocyte Predominance (Paragranuloma) HD |
+ |
+ |
+ |
- |
- |
- |
- |
- |
CD15-; CD30-/+; CD45+; CD57+ T-cells surround L&H cells; EMA+/-; Ig- (us); prom FDC mesh |
Ig & TCR germ; EBV- (mj) |
Nodular Sclerosis HD |
- |
- |
- |
- |
- |
- |
- |
- |
CD15+/-; CD30+; CD45-; EMA- |
Ig & TCR germ (us); EBV+ (40%) |
Mixed Cellularity HD |
- |
- |
- |
- |
- |
- |
- |
- |
CD15+/-; CD30+; CD45-; EMA- |
Ig & TCR germ (us); EBV+ (60-70%) |
Lymphocyte Depletion HD |
- |
- |
- |
- |
- |
- |
- |
- |
CD15+/-; CD30+; CD45-; EMA- |
Ig & TCR germ |
Lymphocyte-Rich Classical HD (provisional entity) |
Similar to Nodular Sclerosis and Mixed Cellularity HD |