NHL Cyberfamily

Non-Hodgkin's lymphoma support

 

CD markers for lymphoma



 

CD Markers for B-cell lymphoma

Below is a chart of the typical CD markers (cluster of differentiation) found on most  lymphomas. These are just one tool the pathologist uses to make a diagnosis.  First is the chart for B-cell types of lymphoma. Below that is the chart for T-cell lymphomas.

Click here for a chart of all CD markers and what they mean.

 

B-cell CD markers

Marker Status
Type CD5 CD10 CD19 CD20 CD21 CD22 CD23 CD43 CD79a sIg cIg
Follicular 1 3 4 4   4 2 1 4 4 0
Nodal marginal zone 1 1 4 4   4 1 2 4 M4, D1 2
MALT 1 1 4 4   4 1 2 4 M4 2
Splenic Marginal zone 1 1 4 4   4 1 0 4 M4 2
CLL/SLL 4 0 4 4   4 4 4 4 D3 2
Lymphoplasmacytic
Waldenstroms
1 1 4 4   4 0 3 4 M4, D2 4
Mantle Cell 4 1 4 4   4 1 4 4 M&D 4 0
Precursor B-cell
(lymphoblastic)
4 3 4 4   4 0 0 4 0 0
Diffuse large B-cell 2 2 4 4   4 0 1 4    
Mediastinal large cell 2                    
Burkitt's 1 4                  
Intravascular B-cell                      
* Footnote: 0 = negative, 1 = <10% positive, 2 10-50% positivity, 3 = 50-90% positivity and 4 = >90% positive

 

T-cell CD markers

Marker Status
Type CD3 CD5 CD7 CD4 CD8 CD30 NK16/56
T-prolymphocytic leukaemia + - + +(-) -(+) - -
T-large granular lymphoproliferative + - + - + - +(-)
Mycosis Fungoides + + + - -(+) -(+) -
Cutaneous ALCL + +(-) +(-) +(-) - ++ -(+)/-(+)
Primary systemic ALCL +(-) +(-) +(-) -(+) -(+) ++ -
Peripheral T-cell lymphoma, unspecified +(-) +(-) -(+) +(-) -(+) -(+) -(+)/-(+)
Subcutaneous panniculitis-like T-cell + + + -(+) +(-) -(+) -/-(+)
Hepatosplenic T-cell lymphoma + - + - - - +/+(-)
Angioimmunoblastic T-cell lymphoma + + - +(-) -(+) - -
Extranodal NK/Tcell lymphoma S -, C + - -(+) -(+) - - -/+
Enteropathy-associated T-cell lymphoma + + + -(+) +(-) +(-) -
Adult T-cell leukaemia/lymphoma + + - +(-) -(+) +(-) -
Footnote: + = >90% positive:  +(-) = >50% positive;  -(+) = <50% positive;  - = <10% positive.
ALCL-Anaplastic large cell lymphoma;  C=Cytoplasmic;  S-Surface.

 

References:

Institute of Biomedical Science

The Cancer network Cancer management Handbook

Medscape (note: article valid only until November 2007 but still online in 2016) Mantle Cell Lymphoma: An Update for Clinicians CME)
http://www.medscape.com/viewarticle/548587_1

More on Pan B-cell markers (CD19, CD20, CD22, CD79a)
http://www.antibodybeyond.com/reviews/cell-markers/b-cell-marker.htm


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